Diosmin is a flavonoid most commonly found in citrus fruits. Flavonoids are plant compounds that have antioxidant properties, which protect your body from inflammation and unstable molecules called free radicals.
Diosmin was first isolated from the figwort plant (Scrophularia nodosa L.) in 1925 and has been used since 1969 as a natural therapy to treat various conditions, such as hemorrhoids, varicose veins, venous insufficiency, leg ulcers, and other circulatory issues .
It’s believed to help reduce inflammation and restore normal blood flow in people with venous insufficiency, a condition in which blood flow is impaired.
Today, Diosmin is widely derived from another flavonoid called hesperidin, which is also found in citrus fruits — especially orange rinds.
Diosmin is often combined with micronized purified flavonoid fraction (MPFF), a group of flavonoids that includes diosmetin, hesperidin, linarin, and isorhoifolin.
Most Diosmin supplements contain 90% Diosmin with 10% hesperidin and are labeled MPFF. In most cases, the terms “Diosmin” and “MPFF” are used interchangeably (3Trusted Source).
This supplement is available over the counter in the United States, Canada, and some European countries. Depending on your location, it may be called Diovenor, Daflon, Barosmin, citrus flavonoids, Flebosten, Litosmil, or Venosmine.
Side effects and precautions
Diosmin is generally recognized as a safe over-the-counter supplement.
Though rare, side effects of Diosmin include stomach pain, diarrhea, headaches, dizziness, skin rash, hives, muscle pain, and — in severe cases — irregular heartbeat (30Trusted Source, 31Trusted Source).
