Glial Cell Electron Microscopy

Brain cells consist of the functional tissue of the brain, mainly including nerve cells (also known as neurons) and glial cells (also known as neuroglia). Ultrastructural measurements of brain cells, including neurons, synapses, and glial cells have provided important insights into normal and abnormal brain cell function. The understanding of ultrastructural characteristics is the basis for in situ revealing cell morphology, cell interaction, organelle distribution, cell niche, and so on. Glial Cell Electron Microscopy https://iem.creative-biostruct....ure.com/brain-cell-i

Plant Organelle Imaging

With the advances in microscopy technology, software development, and detectors, our understanding of plant cell biology has been greatly improved. Based on multiple advanced electron microscopy (EM) techniques, such as scanning electron microscopy (SEM) and cryo-electron microscopy (cryo-EM), Creative Biostructure is able to help researchers gain deeper insight into the fundamental processes of plant cells. Plant Organelle Imaging https://iem.creative-biostruct....ure.com/plant-scienc

Fragment growth

Creative Biostructure provides fragment-to-lead solutions for global customers with drug discovery needs. Through structure-based design, we can optimize the fragment hits into higher affinity compounds which can be utilized as a starting point for drug discovery. Fragment growth https://drug-discovery.creativ....e-biostructure.com/f

high content screening services

The HCS equipment of Creative Biostructure includes a high-resolution automated fluorescence image acquisition system, image analysis and processing software and data management system. Meanwhile, we are also equipped with an automated sample loading module and an environmental control system for long-term automated experimental analysis. high content screening services https://drug-discovery.creativ....e-biostructure.com/h

Coronavirus Crystallography Data Analysis

A new highly pathogenic coronavirus (SARS-CoV-2, provisionally named 2019-nCoV) has swept the world since December 2019. The key to responding to this outbreak is to understand the pathogenic mechanism of the virus. Our understanding of the viral infection process at the molecular and atomic levels depends on the ability to map the structural details of individual biological macromolecules and their interactions with each other and with small molecules. The determination of the three-dimensional (3D) structures of proteins is essential for understanding these interactions and their structure-function relationships, which is beneficial for scientists to develop more effective preventive or therapeutic drugs more quickly. With advanced facilities and years of experience in crystallization and structure determination, Creative Biostructure provides flexible X-ray crystallography services covering all technical stages from gene synthesis to structural analysis to support coronavirus-related research. Coronavirus Crystallography Data Analysis https://www.creative-biostruct....ure.com/coronavirus/